Field Trial Summary

Based on FOI summaries of NADA 134-314 (paste), available through the FDA Center for Veterinary Medicine (CVM)
Active ingredient: Ivermectin

The summary included 45 trials involving 1022 horses:
• 223 treated with paste
• 366 treated by injection
• 281 unmedicated controls (no treatments - some crossovers were treated in later studies)
• 326 positive controls (received other anthelmintics)

Key studies:

Subject - Cutaneous Onchocerciasis (Dermatitis)

• ASR 8750 - Dr. J.A. DiPietro - University of Illinois - 3 horses
• ASR 8775 - Drs. R.P. Herd and J.C. Donham - The Ohio State University - 49 horses
• ASR 10919 - Drs. J.D. Dunsmore and J. Bolton - Murdoch University, Australia - 30 horses
• ASR 10555 - Drs. T.R. Klei and D.D. French - Louisiana State University, - 20 horses

Subject - Dictyocaulus arnfieldi (Summer Sores)

• ASR 7844 - Drs. R.P. Herd and J.C. Donham - The Ohio State University - 31 horses
• ASR 10969 - Dr. J.A. DiPietro - University of Illinois - 7 horses

Subject - Strongyloides westeri

• ASR 10787, 10788, 10789 - Dr. D. Schlichting - West Germany - 21 horses
• ASR 10803 - Dr. H. Heinrich, Merck & Co., Inc. - The Netherlands - 10 horses
• ASR 10783 - Dr. W.G. Ryan, Merck & Co., Inc. - Hertfordshire, U.K. - 16 horses
• ASR 9447 - Drs. M.H. Mirck and G.K. vanMeurs - State University of Utrecht, The Netherlands - 14 horses
• ASR 9729 - Dr. R.L. Asquith -University of Florida Horse Research Center - 20 horses
• ASR 8241, 8242 - Dr. T.M. Craig - Texas A&M University - 64 mares with 63 foals

Subject - Dictyocaulus arnfieldi (Lungworms)

• ASR 9812 - Dr. D.P. Britt - University Veterinary Field Station, Liverpool, U.K. - 12 horses
• ASR 10842 - Dr. E.T. Lyons, Dr. J.H. Drudge and S.C. Tolliver - University of Kentucky - 10 donkeys and 2 horses

Subject - Benzimidazole-Resistant Small Strongyles

• ASR 10543, 10553, 10554, 10642, 10735, 10839 - Drs. Baker, Klei, Craig, Wescott, Asquith - similar trials in various U.S. locations - 36 total horses
• ASR 8766, 8767 - Dr. R.P. Herd - The Ohio State University - 131 horses
• ASR 11019 - Dr. F. Garcia Laborde -- Buenos Aires, Argentina - 35 horses
• ASR 10621, 10991 - Dr. L.F. Uribe - Merck & Co., Inc. - Cundinamarca, Columbia - 50 total horses
• ASR 8648, 8714, 8715, 8980, 8981, 9226, 9227, 8856, 8857, 8858, 8859, 9138, 10004, 10005, 10006, 10007, 10008, 10009 - Dr. M.J. Lindsey, Dr. R.O. Burrows, and R.S. Smith - Merck, Sharp & Dohme Research Laboratory - New South Wales, Australia; plus Mr. G.C. Cairns - Merck, Sharp & Dohme Research Laboratory - Christchurch, New Zealand - 239 total horses

HORSE HEALTH Equine Ivermectin Mode of Action - an informal summary of how it works to kill parasites

To develop and survive in your horse's system, parasites must:

• Maintain an appropriate feeding site
• Actively ingest and move food through their digestive tracts
• Maintain neuromuscular coordination for digestion and reproduction
• Maintain homeostasis in the face of immune reactions in the horse's system.

HORSE HEALTH acts as a Potentiation of Inhibitory Transmitters.

• It interferes with the life support requirements of the parasite
• It inhibits the action of the parasite's neurotransmitters
• Interferes with parasite's neuromuscular coordination
• Interferes with the parasite's protective mechanisms against immune response
• Often leads to paralysis, starvation, and expulsion of the parasite.

HORSE HEALTH acts with selective toxicity

• It inhibits the life systems of the parasite, without interfering with comparable functions in your horse.
• This is also known as differential toxicity

HORSE HEALTH is safe for use on all horses, including broodmares, stallions and foals without age restrictions.